![]() The contact information of the ethics Committee of Kempenheaghe is: Kempenhaeghe Dr. The local Medical Ethical Committee of Kempenhaeghe imposes the data sharing. The regular clinical care data are owned by the centre of Neurological Learning Disabilities of Kempenhaeghe and sharing data is imposed by the research ethics committee of Kempenhaeghe. The data of the participants used in current study contain regular clinical care data and contains potentially identifying and sensitive data since the amount of DMD males living in the netherlands having comorbid disorders and receiving psychological care is limited and thus data may be easily identified even when sharing a de-identified data set. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: As there is a possibility to identify participants based on their clinical and neurocognitive data, the datasets generated and/or analyzed during the current study cannot be made publicly available based on European Law. Received: FebruAccepted: SeptemPublished: October 10, 2022Ĭopyright: © 2022 Hellebrekers et al. (2022) Cognitive and behavioral functioning in two neurogenetic disorders how different are these aspects in Duchenne muscular dystrophy and Neurofibromatosis type 1? PLoS ONE 17(10):Įditor: Atsushi Asakura, University of Minnesota Medical School, UNITED STATES In the neurogenetic disorders DMD and NF1, on average overlapping cognitive and behavioral problems are noticed, suggesting that these are not only caused by gene mutations resulting in a lack of one specific protein.Ĭitation: Hellebrekers DMJ, van Abeelen SAM, Catsman CE, van Kuijk SMJ, Laridon AM, Klinkenberg S, et al. Outcomes of questionnaires displayed higher rates of aggressive behavior (13.2%) in DMD, whereas in NF1 higher rates of problems with thinking (15.8%), withdrawn (10.5%) and social behavior (10.5%) were noticed. Simultaneous processing, verbal memory and sustained attention outcomes were equal for both groups. Males with DMD exhibited low intellectual abilities and sequential processing problems, but these outcomes not significantly differed from males with NF1. In addition, parents and teachers completed behavioral questionnaires. Intellectual abilities, sequential and simultaneous processing, verbal memory and sustained attention were evaluated. Patients of both groups underwent neurocognitive assessment for regular clinical care. Retrospective data of 38 male patients with DMD were aged-matched with data of 38 male patients with NF1. ![]() This study aims to assess disorder specific differences in cognition and behavior between DMD and NF1. However, comparable cognitive and behavioral problems have been found in Neurofibromatosis type 1 (NF1). In Duchenne muscular dystrophy (DMD), these problems have been linked to mutations along the dystrophin gene affecting different brain dystrophin isoforms. The presence of neurocognitive and behavioral problems are common features in various neurogenetic disorders. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |